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Project

Detailed study of protein-protein interactions: study of the activation mechanism of TOLL-like receptors

Toll-like receptors are activated by interactions between TIR domeins. Homology models are built for the TIR domains. The MAPPIT method and in vitro binding studies with recombinant TIR domains are combined with extensive mutagenesis studies to identify the interaction interfaces. These data are used as input for data-driven in silico docking. This leads to experimentally validated models for TIR-TIR complexes.

Date:1 Jan 2008 →  31 Dec 2010
Keywords:homology modelling, toll-like receptor, innate immunity
Disciplines:Bioinformatics and computational biology, Public health care, Biological system engineering, Scientific computing, Medical biochemistry and metabolism, Other (bio)medical engineering, Biochemistry and metabolism, Other biotechnology, bio-engineering and biosystem engineering, Biomaterials engineering, Systems biology, Public health services, Industrial biotechnology, Biomechanical engineering, Environmental engineering and biotechnology