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Project
Nucleophilic Nanoparticles for optimal delivery of plasmid DNA in dividing cells
Plasmid DNA needs to reach the cell nucleus to be biologically active. We aim to explore new strategies to target naked DNA or DNA nanoparticles to the cell nuclei of daughter cells during the cell division of the mother cell, since during cell division the intracellular barrier of the nuclear membrane is temporarily broken down.
Date:1 Oct 2007 → 30 Sep 2014
Keywords:plasmid DNA, non-viral gene therapy, nuclear membrane
Disciplines:Biomaterials engineering, Chemical product design and formulation, Other pharmaceutical sciences, Pharmaceutics, Process engineering, Biomarker discovery and evaluation, Pharmacotherapy, Pharmacology, Toxicology and toxinology, Medicinal products, Pharmacognosy and phytochemistry, Polymeric materials, Drug discovery and development