Study of the essential function of beta-actin in embryonic development and the necessity of correct localisation of beta-actin mRNA in neuronal development

The actin cytoskeleton is the driving force for various cell motility processes. Little is known about the function of the six actin isoforms during mammalian development. During this PhD, we will investigate how loss of beta-actine influences angiogenesis and neurogenesis during embryogenesis and how mislocalisation of beta-actine mRNA leads to aberrant neuronal differentiation and angiogenesis.