Tes, a cancer-associated LIM-domain protein and novel actin nucleator with a dual function in the cytoplasm and the nucleus

Cell migration is an important process in preserving health. The actin cytoskeleton regulates cell migration and deregulation is often associated with cancer progression. Tes, a potential tumor suppressor, possibly acts as a bi-functional sensor with cytoplasmic and nuclear activity. A structure-function relationship study of Tes and partners using proteomics, medium throughput cell migration assays and microarray experiments will be conducted.