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Project
The role of prolyl hydroxylases in endothelial dysfunction in the pathogenesis of Non-Alcoholic Steatohepatitis
Non-alcoholic steatohepatitis (NASH) is characterized by liver inflammation and fat accumulation. Pathological neo-angiogenesis is a crucial factor in experimental NASH. With this project we aim to clarify the role of prolyl hydroxylases (PHD), the cellular oxygen sensors, in NASH. The expression of PHDs and the effects of PHD inhibition will be evaluated in human samples and murine models respectively.
Date:1 Oct 2015 → 30 Sep 2019
Keywords:Non-alcoholic steatohepatitis, endothelial dysfunction
Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Other paramedical sciences, Other medical and health sciences, Other translational sciences, Other clinical sciences, Immunology, Nursing