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Project

Unraveling the segregation pattern of mitochondrial DNA mutations using embryos and pluripotent stem cells

As there is no cure for mitochondrial (mt) diseases yet, it is highly important to prevent the transmission of mtDNA mutations. For this, we want to determine the mtDNA mutation load of embryos accurately by using next generation sequencing. Moreover, pluripotent stem cells from these patients serve as a unique model to study the mtDNA segregation pattern in detail.

Date:1 Mar 2016 →  31 Aug 2019
Keywords:embryos, mitochondrial disorders, pluripotent stem cells
Disciplines:Gynaecology and obstetrics, Endocrinology and metabolic diseases, Genetics, Morphological sciences, Molecular and cell biology, Nursing