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Project
In vivo evaluation of non-viral mRNA delivery systems for mRNA vaccination against cancer.
We will evaluate non-viral delivery systems for mRNA vaccination against cancer in mouse-models. Therefore, we will first study the biodistribution, the level and the kinetics of the gene expression of mRNA/liposome or mRNA/polymer complexes in mice. Additionally, the immunological response and tumor growth will be evaluated after the delivery of a mRNA vaccine complexed with the most efficient non-viral delivery system.
Date:1 Oct 2009 → 30 Sep 2014
Keywords:gene therapy, non-viral delivery systems, anti-cancer immunity, mRNA vaccination
Disciplines:Pharmaceutics, Morphological sciences, Drug discovery and development, Immunology, Biomarker discovery and evaluation, Pharmacology, Oncology, Pharmacotherapy, Toxicology and toxinology, Pharmacognosy and phytochemistry, Medicinal products, Other pharmaceutical sciences