Disturbance of the cytoskeleton-plasmamembrane interactions results in intercalated disc malformation and induces cardiomyopathy

Arrhythmogenic Ventricular Cardiomyopathy (AVC) is a genetic, progressive heart condition with abnormal heart rhythm and malfunction of the ventricles. AVC is often caused by mutations in proteins belonging to the areae compositae localized at the intercalated disc. Crucial is the link with the cytoskeleton. This project aims to gain more insights into this link and its contribution to cell-cell interactions and mechanotransduction