The pathomechanism of spontaneous peripheral neuropathy in aging rats

In ageing rats, there is a high incidence of spontaneous peripheral neuropathy, resulting in hind limb paresis, evolving to complete hind limb

paralysis. Lesions developing in the rats’ peripheral nervous system will be followed up

in vivo, using Diffusion Tensor Imaging (DTI) and electrophysiological examination. Thereafter, early pathobiology of the disorder will be studied more in depth.