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Project
Interaction between Fusarium mycotoxins and cytochrome P450 drug metabolizing enzymes and ABC drug transporters in a porcine animal model
Mycotoxins are feed and food contaminants which can modulate the expression of genes encoding for CYP450 enzymes and ABC drug transporters and/or may modulate their activity. The goal of this research proposal is to investigate the effect of mycotoxin intake on the pharmacokinetic behavior of CYP450 and ABC substrate drugs in a pig animal model.
Date:1 Oct 2015 → 30 Sep 2019
Keywords:pigs, drugs, animal model, mycotoxins, Metabolisme
Disciplines:Other veterinary sciences, Pharmaceutics, Medicinal products, Other pharmaceutical sciences, Other agricultural, veterinary and food sciences, Pharmacognosy and phytochemistry, Veterinary medicine, Toxicology and toxinology, Drug discovery and development, Pharmacotherapy, Animal biology, Pharmacology, Biomarker discovery and evaluation