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Project

Evaluation of mRNA loaded microbubbles for untrasound guided cancer vaccination

Dendritic cells, the professional antigen-presenting cells of our immune system, induce cytotoxic T lymphocyte responses against tumor-associated antigens. Consequently, there has been much interest in their application as anti-tumor vaccines. In this study we willcombine the expertise of the GRGN and LMCT to evaluate the use of mRNA-loaded microbubbles and ultrasound to modify DCs ex vivo as well as intradally to boost anti-tumor immunity. These data together with the fact that the use of mRNA-loaded microbubbles could provide a way to manipulate DCs in vio, warrant an in dept evaluation of this mRNA-loaded microbubble-based vaccination strategy.

Date:1 Jan 2013 →  31 Dec 2018
Keywords:immunotherapy, mRNA, cancer vaccination, microbubbles, ultrasound, TriMix
Disciplines:Palliative care and end-of-life care, Laboratory medicine, Other health sciences, Other clinical sciences, Regenerative medicine, Other basic sciences, Nursing, Other paramedical sciences, Other medical and health sciences, Other translational sciences