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Project

The role of ZEB transcription factors in malignant progression and therapy resistance in high grade serous ovarian cancer

Epithelial ovarian cancer is the most lethal of all gynecologic malignancies. This poor prognosis is mainly due to a delayed diagnosis resulting in advanced stage of disease and frequent therapy-resistant relapses.  We will address the role of the EMT (epithelial mesenchymal transition) inducing transcription factors ZEB1 and ZEB2 in tumor initiation, progression, metastasis and therapy-resistance in high-grade serous ovarian carcinoma.  

Date:1 Oct 2016 →  15 May 2021
Keywords:Ovarian cancer
Disciplines:Oncology, Laboratory medicine, Regenerative medicine, Gynaecology and obstetrics, Palliative care and end-of-life care, Endocrinology and metabolic diseases, Other clinical sciences, Other health sciences, Molecular and cell biology, Other paramedical sciences, Systems biology, Other basic sciences, Genetics, Other medical and health sciences, Morphological sciences, Nursing, Other translational sciences