The role of cathepsins in apoptosis and antigen presentation studied by positional proteomics

Positional proteomics to isolate N- and C-terminal peptides will be used for detailedanalyses of substrates and functions of cathepsins. Substrate catalogues of recombinantcathepsins will be generated, substrates cleaved during cell death in a mouse cellularmodel system will be mapped and the individual roles of cathepsins D and E in MHCclass II antigen presentation will be established.