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Project
Epigenetic re-activation of T-ALL tumor suppressors under control of TLX1driven enhancer RNAs.
In this project, I will further explore the oncogenic role of TLX1 in the development of T-cell acute lymphoblastic leukemia. This research will explore a network connecting TLX1 with long noncoding RNAs and tumor suppressor genes. Ultimately, this should allow identification new vulnerable nodes for targeted therapy of TLX1-driven T-ALLs.
Date:1 Oct 2015 → 30 Sep 2019
Keywords:TLX1, T-ALL, enhancers, epigenetics, lncRNAs
Disciplines:Molecular and cell biology, Morphological sciences, Oncology, Systems biology, Other biological sciences, Genetics