Investigating the radioprotective mechanisms of biotic food supplements using human gut organoids-derived bioreactor.

The aim of this PhD project is to determine the radioprotective mode of action of biotic food supplements including LGG and Limnospira sp.. First (WP1), we will implement the newly GuMI platform using human gut derived organoids and CRC tumoroids, in a radiotherapy relevant setup which has never been done before, then (WP2) to investigate barrier protective and immunomodulatory mechanisms of action of LGG and Limnospira sp. either individually and in a symbiotic combination, and in parallel (WP3) to continue the search for new radioprotective agents of natural origin taking advantage of the higher screening throughput and human physiological applicability provided by the GuMI platform compared to mouse studies. This could also include the use of FMT, as a more holistic gut microbiome-based therapy.

Keywords:PROBIOTICS

Disciplines:Bacteriology

Project type:Collaboration project