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Project

Inherited predisposition for breast cancer in the next generation sequencing era: evaluation of the role of genes involved in homologous recombination and G2/M checkpoint control and decelopment of a functional assay.

In less than 20% of the familial breast cancers a germline mutation in the major breast cancer genes BRCA involved in hte same pathway by a next generation sequencing approach. Furthermore, we will develop a functional assay to elucidate the role of variants of unknown significance.

Date:1 Mar 2013 →  31 Dec 2017
Keywords:next generation sequencing, hereditary breast cancer, funtional assay
Disciplines:Medical systems biology, Systems biology, Molecular and cell biology, Laboratory medicine, Genetics