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Project

Role of ER stress in the angiogenesis associated with liver cirrhosis and portal hypertension

Models of portal hypertension and cirrhosis are used to study the role of ER stress in the development of angiogenesis and fibrosis in the liver and splanchnic circulation. We hypothesize that in PHT and cirrhosis, strategies inhibiting ER stress (by using silencing RNAU+2019s or JIK/Tao3K knockout mice) can decrease inflammation and hypoxia leading to less angiogenesis and fibrosis formation. But that on the other hand, strategies normalising neo-vessels or inhibiting angiogenesis with anti-PLGF may reduce ER stress and hypoxia.

Date:1 Jan 2012 →  31 Dec 2017
Keywords:cirrhosis, portal hypertension, ER stress, angiogenesis
Disciplines:Gastro-enterology and hepatology