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Project
Development of C-terminal peptide-based proteome-analytical strategies and the extensive mapping of the granzyme substrate-repertoire
This project involves the development of proteome-wide strategies for the isolation of C-terminal peptides. As such, the sample complexity is reduced to a maximum since each final protein is represented by a single peptide. By the combined use of N-and C-terminal COFRADIC, one can obtain a full proteome coverage, thereby enabling the extensive mapping of protease substrate-repertoires.
Date:1 Jan 2010 → 31 Dec 2012
Keywords:substrates, protease, cofradic
Disciplines:Medical biochemistry and metabolism, Systems biology, Biochemistry and metabolism