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Project
Characterization of the unique molecular network that controls T cell development.
T-lymphocytes are derived from hematopoietic stem cells and their differentiation depends on the integration of multiple transcriptional regulators such as GATA3, TCF1, BCL11B and Notch signaling. The kinetics and expression levels of these factors are critical for T-cell development. In this project, we wish to investigate how these factors
interact to modulate downstream gene expression during normal human T-cell development.
Date:1 Oct 2013 → 30 Sep 2016
Keywords:transcription factors, Notch Signaling, T-cell diferentiation, hematopoietic stem cells
Disciplines:Hematology, Palliative care and end-of-life care, Other medical and health sciences, Regenerative medicine, Other health sciences, Laboratory medicine, Other translational sciences, Other paramedical sciences, Immunology, Other clinical sciences, Other basic sciences, Systems biology, Nursing