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Project
Role of hypoxia in dendritic cell biology and pathogenesis of asthma
Dendritic cells (DCs) play a critical role in the induction of allergic asthma. Metabolic factors like hypoxia-sensing modulate the initiation and course of inflammatory diseases. Our hypothesis is that in inflammatory processes DCs interprete hypoxia as a danger signal. We will examine the role of hypoxia on DC biology by testing specific transgenic mice in a mouse-model of asthma.
Date:1 Oct 2010 → 5 Jan 2016
Keywords:asthma, hypoxia, dendritic cell, immunology
Disciplines:Regenerative medicine, Other health sciences, Other biological sciences, Other medical and health sciences, Other basic sciences, Other clinical sciences, Palliative care and end-of-life care, Immunology, Laboratory medicine, Other paramedical sciences, Other translational sciences, Nursing