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Project
Role of the mycobacterial cell wall lipids, myocolic acids, in the control of ontracellular replication of mycobacterium tuberculasis bacilli
With this aim to develop new therapeutic approaches to (drug-resistant- tuberculosis, we aim to wetermine how mycobacterial cell wall mycolic acids interfere ith the host cell function and hereby facilitate intracellular replication of the bacilli. Using mouse models, the interrelation between mycolic acids-facilitated intracellular replication, disturbed macrophage cholesterol metabolic pathways and the cholesteroid nature of mycolic acids will be verified.
Date:1 Nov 2010 → 31 Oct 2015
Keywords:mycolic acid, mycobacterium tuberculosis, macrophage, cholesterol
Disciplines:Immunology, Laboratory medicine, Microbiology, Systems biology