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Project
Involvement of human B-lymphocytes in the transmission of hepatitis C virus infections
Our team created a small animal model in which wild-type hepatitis C virus (HCV) infections can be studied. Recently we succeeded in infecting these chimeric mice with B-lymphocytes purified from a chronic HCV patient. This project focuses on the human B-lymphocytes which are a reservoir for infectious HCV virus. Furthermore, the clinical implications of B-cell mediated HCV transmission are analyzed.
Date:1 Jan 2010 → 31 Dec 2014
Keywords:chimeric mice, immunology, B-lymphocytes, HCV
Disciplines:Regenerative medicine, Gastro-enterology and hepatology, Other clinical sciences, Palliative care and end-of-life care, Other basic sciences, Other medical and health sciences, Other translational sciences, Immunology, Laboratory medicine, Nursing, Other paramedical sciences, Microbiology, Other health sciences