Choroidal and Choriocapillaris Morphology in Pan-FGFR Inhibitor-Associated Retinopathy: A Case Report

Emerging anticancer agents such as the pan-FGFR Inhibitor have achieved remarkable improvements in the survival of patients with metastatic malignancies. Nevertheless they are still associated
with specific ophthalmic toxicities. Understanding their pathophysiology can lead us to better clinical
practice of life-threatening and vision-threatening circumstances. To investigate choroidal alterations
as a potential pathophysiological mechanism of a serous detachment in bilateral pan-FGFR InhibitorAssociated Retinopathy (FGFRAR), the morphology of the choroid and choriocapillaris were assessed.
The choroidal thickness (ChT) and choriocapillaris flow void were measured by macular optical coherence tomography (OCT) and angiography (OCT-A), respectively. Data were collected at the baseline,
then at one-month and two-months follow-ups after starting erdafitinib, in a single case of pulmonary
angiosarcoma. Choroidal and choriocapillaris morphology showed stable ChT and choriocapillaris flow
void at FGFRAR onset and relapse. To the best of our knowledge, this is the first analyzed case reported
with flow-void OCT-angiography. Considering these results, FGFRAR in this patient does not seem
to match the pachychoroid spectrum disorder definition; rather, an intracellular mechanism based on
intracellular transduction pathways may be at wo

Publication year:2022

Keywords:choroidal and choriocapillaris morphology; pan-FGFR Inhibitor-Associated Retinopathy; OCT-angiography; retinal serous detachment; pachychoroid spectrum disease

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