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Patent

Halogenated benzotropolones as ATG4B inhibitors

The present invention relates to compounds having a benzotropolone core, and compositions containing said compounds acting as ATG4B inhibitors, thereby inhibiting autophagy. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the treatment of cell proliferative disorders, such as cancer.
Patent Publication Number: US10738002
Year filing: 2020
Year approval: 2020
Year publication: 2020
Status: Assigned
Technology domains: Organic fine chemistry, Pharmaceuticals
Validated for IOF-key: Yes
Attributed to: Associatie Universiteit & Hogescholen Antwerpen