Antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4H-pyrrolo[1,2-?][1,4]benzodiazepine and 4-(difluoroethyl)phenyl-6H-pyrrolo[1,2-?][1,4]benzodiazepine derivatives

The present invention concerns novel compounds of Formula (I): wherein R1, R2, R3, R4, R5 and R6 have the meaning defined in the claims. The compounds according to the present invention are active mainly against dermatophytes and systemic fungal infections. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Patent Publication Number: US9637490

Year filing: 2011

Year approval: 2017

Year publication: 2017

Status: Assigned

Technology domains: Pharmaceuticals

Validated for IOF-key: Yes

Attributed to: Associatie Universiteit & Hogescholen Antwerpen