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Patent
3-(benzylamino)-4-(cyclohexylamino)-n-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 analogues as cell death inhibitors for treating e.G. stroke
The present invention relates to 3-(benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 (Fer-1) analogues as cell death inhibitors by inhibition of ferroptosis and/or oxytosis for the treatment of stroke, myocardial infarction, diabetes, sepsis, the prevention of transplant rejection, neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, dementia with Lewy bodies and Friedreich's ataxia. The present invention further relates to pharmaceutical compositions of these compounds and discloses methods for making the compounds and the corresponding intermediate.
Patent Publication Number: WO2019154795
Year filing: 2019
Year approval: 2020
Year publication: 2019
Status: Requested
URI: link to Espacenet
Technology domains: Pharmaceuticals
Validated for IOF-key: Yes
Attributed to: Associatie Universiteit & Hogescholen Antwerpen, Associatie Universiteit Gent
- See also: COMPOUNDS FOR INHIBITING CELL DEATH