Multiparametric brain imaging in yoga versus physical activity: a simultaneous PET/MR study in healthy subjects

The neurobiology of yoga practice : an interventional multiparametric PET-MR studyYoga is increasingly practiced not only in the healthy population but also as a complementary approach in cancer and psychiatric disorders such as depression and post-traumatic stress. Although the core aspects of postures, meditation and breathing techniques are central in different forms of yoga, there is strong heterogeneity and the effect on health and wellbeing has scarcely been investigated in a rigorous and controlled scientific setup, and very seldomly using objective central (brain) biomarkers.In this project, we want to use simultaneous PET-MR imaging and neuropsychological standardized evaluations to investigate neurobiological underpinnings of the effect that yoga has on the human brain. One of the central hypothesis is that yoga augments parasympathic tone through vagal nerve afferents, thereby increasing GABA-ergic tone, resulting in limbic and cortical network reorganisation and long-term functional (neurotransmitter and hormonal) and morphological (e.g. insular) changes in the brain.We will investigate in a longitudinal study the effect of a standardized three-component yoga practice in novices using PET-MR (absolute glucose metabolism, rsfMRI, DTI and sMRI) in a 2x2 design, with physical exercise as control group. These parameters will also be investigated in a cross-sectional design between experienced teachers and beginner practitioners. The molecular changes on the GABA-ergic system (GABA-A receptor PET and MRS) will be investigated in a second stage. Thirdly, in patients with breast cancer and major depressive disorder, we will investigate the effect of yoga as complimentary to standard care using the network and regional neurochemical information obtained from the pilot studies in healthy subjects.J. van AalstK. Van Laere

Publication year:2021

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