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Publication

Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain

Journal Contribution - Journal Article

Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.
Journal: Biomaterials Science
ISSN: 2047-4830
Volume: 8
Pages: 4997 - 5004
Publication year:2020
Keywords:A1 Journal article
BOF-keylabel:yes
BOF-publication weight:3
CSS-citation score:2
Authors:International
Authors from:Higher Education
Accessibility:Open