Palladium-catalyzed post-Ugi arylative dearomatization/Michael addition cascade towards plicamine analogues

A palladium-catalyzed intramolecular cyclization of Ugi-adducts via a cascade dearomatization/aza-Michael addition process has been developed. Diverse plicamine analogues are constructed in a rapid, highly efficient and step-economical manner, through the combination of an Ugi-4CR and a palladium-catalyzed dearomatization. The synthetic utility of this approach is illustrated by further functional group transformations.

Publication year:2021

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Authors:International

Authors from:Higher Education

Accessibility:Open