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Project

Analytical and environmental novel insights in the human exposure to Synthetic ANTioxidants by Advanced mass spectrometry (SANTA)

Within the indoor environment, humans are exposed to a diverse group of contaminants of emerging concern (CECs), who remain largely understudied. Two groups of ubiquitous CECs, namely the high molecular weight phenolic antioxidants (HMW SPA) and the organic phosphite antioxidants (OPA), have received little attention in literature. These novel antioxidants exposure has only been accessed in Asia and North-America by applying methods that focus on a small subset of novel antioxidants (AOXs). Therefore, the goal of this project is to develop both qualitative and quantitative exposure methods, including a human biomonitoring method for novel AOXs metabolites. These innovative methods will be applied in Flanders, providing the first exposure studies in Europe for the novel AOXs. This goal will be achieved by employing state of the art mass spectrometry (MS) equipment coupled to liquid or gas chromatography. By developing target and non-target MS screening methods and applying novel techniques such as iterative MS within the screening methods. This project will result in the first biomonitoring method of novel AOX metabolites accessing human exposure in Flanders. The developed methods can be used in upcoming European biomonitoring programs, accessing exposure on a larger scale. In conclusion, this project will be of great added value as it will be the first in Europe to access human exposure to novel antioxidants by employing innovative techniques.
Date:1 Nov 2021 →  31 Oct 2022
Keywords:MASS SPECTROMETRY, ANTIOXIDANTS
Disciplines:Analytical separation and detection techniques, Analytical spectrometry, Other environmental sciences not elsewhere classified, Analytical toxicology