< Back to previous page

Project

Proton therapy and the developing connectome in pediatric brain tumors

Previous studies have shown that cranial irradiation of paediatric brain tumours with conventional photon (X-ray) beam radiotherapy (XRT) can cause alterations in the brain. These alterations, quantified by multimodal neuroimaging studies, were previously related to neurocognitive decline, long-term neurotoxicity and impairment of quality of life. Nevertheless, the major targets of neural damage remain unclear and the XRT effect on connectome and neurocognitive functioning is unclear. In addition, it is important to understand the importance of specific brain areas and their functionality in order to optimise radiation delivery, as avoiding these areas could limit neurotoxicity. Proton beam radiotherapy (PBT) can spare more healthy brain tissue due to its specific physical properties including decreased scatter. Studies on this innovative treatment modality are scarce but PBT might limit the treatment impact on neurocognitive functioning. Its potential therefore needs to be further explored, with particular attention to neural damage and dose-dependence. In this study, state-of-the art multimodal neuroimaging protocols will be combined with in-depth neurocognitive assessments. This will be done to determine the radiation-induced neurological impact on paediatric brain tumour patients. This knowledge can contribute to a radiotherapy protocol that avoids the critical brain regions and limits the neurotoxic effects.

Date:1 Dec 2021 →  Today
Keywords:pediatric brain tumors, proton beam therapy, connectome, neurocognitive functioning
Disciplines:Medical imaging and therapy not elsewhere classified, Cancer therapy, Cognitive neuroscience
Project type:PhD project