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Project

Understanding the cellular phase of Alzheimer’s disease using spatial transcriptomics

The cellular phase of Alzheimer’s disease is the long and complex phase within the disease’s continuum that follows the biochemical phase and precedes the clinical phase. It is marked by the interplay of various inhibitory and excitatory cell types, including neurons, neuronal networks, microglia, astroglia, and, oligodendrocytes, as well as defective amyloid-beta and tau clearance mechanisms. Through the integration of spatial and multi-omics data, this project will seek to unravel the spatial and transcriptional changes of these individual cell types in the vicinity of amyloid-beta plaque deposits. Insights gathered will serve to create a more comprehensive understanding of the cellular response to Alzheimer’s pathology, with the hope of informing future prevention and therapeutic strategies

Date:1 Sep 2021 →  Today
Keywords:spatial transcriptomics, multi-omics, cellular phase, RNA-Seq, single-cell, ATAC-Seq, Alzheimer's Disease
Disciplines:Bioinformatics of disease
Project type:PhD project