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Advances in ultra‐high‐pressure and multi‐dimensional liquid chromatography instrumentation and workflows

Journal Contribution - Journal Article

The present contribution discusses recent advances in ultra‐high‐pressure liquid chromatography (UHPLC) and multi‐dimensional liquid chromatography (MDLC) technology. First, new developments in UHPLC column technology and system design are highlighted. The latter includes a description of a novel injector concept enabling method speed‐up, emerging detectors, and instrument diagnostics approaches. Next, online MDLC workflows are reviewed and advances in modulation technology are highlighted. Finally, key applications published in 2020 are reviewed.
Journal: Analytical Science Advances
ISSN: 2628-5452
Issue: 3-4
Volume: 2
Pages: 171-192
Publication year:2021
Keywords:UHPLC, Two-dimensional liquid chromatography, 2D-LC, spatial 3D LC
Accessibility:Open