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Project

Transcriptome-based management of transplant-related pulmonary fibrosis in chronic pulmonary rejection after lung or allogeneic stem cell transplantation

Background Chronic lung allograft dysfunction (CLAD) and chronic pulmonary graft versus host disease (cGvHD) are life-threatening conditions commonly encountered after lung transplantation and allogeneic hematopoietic stem cell transplantation. Pathophysiological and molecular pathways associated with transplant-related pulmonary fibrosis leading to structural changes and lung failure in CLAD pulmonary cGvHD remain unknown. Aims The primary objective of this translational research project is to investigate the pathways and targets involved in transplant-related pulmonary fibrosis in obstructive and restrictive phenotypes of CLAD and lung cGvHD, in order to identify novel diagnostic markers and improved therapeutics, allowing to better manage rejection-mediated fibrotic lung remodeling. Methods A multi-modal approach, using human bio-samples, assessing structural organization, immunopathologic findings and transcriptome analysis of CLAD and pulmonary cGvHD. Expected results This project will gain novel, breakthrough insights in the pathophysiology of CLAD and pulmonary cGvHD, lead to novel diagnostic and better therapeutic tools, allowing for improved, personalized medical management; and result in better long-term outcomes in patients undergoing lung transplantation and allogeneic hematopoietic stem cell transplantation.

Date:1 Oct 2021 →  Today
Keywords:Lung transplantation - Chronic lung allograft dysfunction Allogeneic hematopoietic stem cell transplantation - Chronic pulmonary graft versus host disease Immunopathologic organization - Transcriptome analysis (mRNA sequencing)
Disciplines:Respiratory medicine
Project type:PhD project