A pipeline for the development of lysins as decolonizing agents against vancomycin-resistant enterococci.

Lysins are bacteriophage-encoded peptidoglycan degrading enzymes with proven clinical potential as alternative for broad-spectrum antibiotics. In this project, I will develop a pipeline for discovery, engineering and delivery of lysins in the gut environment for pathogenic decolonization. A generic
approach will be elaborated for lysins, here specifically acting against vancomycin-resistant enterococci (VRE).