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Project
Immune profiling and the role of monocyte/macrophage populations in primary sclerosing cholangitis and related ulcerative colitis.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease frequently associated with intestinal inflammation, mainly ulcerative colitis. The etiopathogenesis has not been elucidated but compromises in the gut-liver crosstalk are suggested in which macrophages are implemented. The immunological profile and importance of monocyte-/macrophage-populations will be investigated, including the role of macrophage-Trem2, a recently identified marker in experimental PSC/colitis.
Date:1 Oct 2021 → 31 Oct 2021
Keywords:gut-liver axis, Primary sclerosing cholangitis, ulcerative colitis, macrophages
Disciplines:Gastro-enterology, Hepatology, Innate immunity, Inflammation, Gastro-enterology and hepatology not elsewhere classified