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The impact of prurigo nodularis on quality of life

Journal Contribution - Journal Article

Subtitle:a systematic review and meta-analysis

Prurigo nodularis (PN) is a chronic, pruritic, debilitating disease. Previous studies found that chronic pruritus in general negatively affects patients' quality of life (QoL). However, results about the impact of PN on QoL are conflicting. Our objective was to assess the QoL burden of PN. A systematic review was conducted of all published studies that assessed QoL measures in PN. OVID MEDLINE, EMBASE, SCOPUS, and Web of Science were searched. Pooled meta-analysis (means) was performed using random-effects weighting. Overall, 13 studies met inclusion criteria. All studies identified QoL reductions in patients suffering from PN compared to control groups. The most common QoL instrument used was the Dermatology Life Quality Index [n = 9 studies; pooled mean (95% confidence interval): 13.8 (10.6-16.9), denoting a very large effect]. In particular, PN was associated with substantial impact on multiple domains of QoL. No publication bias was detected. In conclusion, QoL is negatively impacted in PN. Future studies are necessary to determine the best instruments of measuring QoL in PN patients, better understand this association, and assess the impact in males and females separately. PROSPERO CRD42019136193.

Journal: Arch Dermatol Res
ISSN: 0340-3696
Issue: 8
Volume: 313
Pages: 669-677
Publication year:2021
Keywords:Besnier, Chronic itch, EQ5D, Hyde’s prurigo, IchyQoL, Itch, Meta-analysis, NRS, Nodular prurigo, Prurigo, Prurigo nodularis, Pruritis, Pruritus, Quality of life, Systematic review, VAS, VRS
BOF-keylabel:yes
IOF-keylabel:yes
BOF-publication weight:1
Authors:International
Authors from:Higher Education
Accessibility:Closed