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Interplay of Val66Met and BDNF methylation: effect on reward learning and cognitive performance in major depression

Journal Contribution - Journal Article

There is a growing interest in the role of brain-derived neurotrophic factor (BDNF) in major depressive disorder (MDD). BDNF potentially exhibits opposite effects in the pathways linked to anhedonia and reward learning on the one hand and cognitive performance, on the other hand. However, the epigenetic mechanisms behind this remain unknown. In the present study, we aimed to investigate the interplay of DNA methylation of different BDNF exons and the common Val66Met polymorphism on anhedonia, reward learning and cognitive performance in MDD.
Journal: Clinical Epigenetics
ISSN: 1868-7083
Issue: 1
Volume: 13
Pages: 149 - 149
Publication year:2021
BOF-keylabel:yes
IOF-keylabel:yes
BOF-publication weight:3
CSS-citation score:1
Authors:International
Authors from:Private, Higher Education
Accessibility:Open