Methodological developments to map the myelin-specific T-cell receptor sequence space.

T-cell immunity is a key player in the development and progression of multiple sclerosis (MS). The T-cell receptor (TCR) expressed on the cell surface of T-cells is one of the primary determinants of self versus non-self. The composition of the TCR sequence space targeting MS-involved antigens, such as myelin, is currently poorly characterized. We hypothesize that the TCR space holds invaluable knowledge which may unlock the molecular mechanisms of self-antigen reactivity. To this end, we aim to map the MS antigen-specific TCR space with state-of-the-art immunoinformatics data mining models.

Keywords:MULTIPLE SCLEROSIS, T-LYMPOCYTES, DATA MINING

Disciplines:Analysis of next-generation sequence data, Development of bioinformatics software, tools and databases, Adaptive immunology