IOF PoC “MOTIF: MOdification of T cells In situ for altered Functionality” (IOFPOC42)

In the MOTIF research project we aim to develop new nanobodies against a T-cell-specific membrane protein. These nanobodies will be conjugated on the envelope of viral vector, hereby selectively infecting and transducting the T-cells. We will additionally employ genetically-modified mice to test these engineered viral vectors in an optimal manner..

Keywords:T cells, in situ, Nanobodies, Viral transduction, Genetically-engineered mice

Disciplines:Molecular and cell biology not elsewhere classified

Project type:Collaboration project