Antibacterial dose optimisation based on augmented renal clearance in adult critically ill patients and selected pediatric patients

With this postdoctoral research, the candidate will take the step up towards the implementation of previously gathered knowledge. During his PhD, detailed insights into antibiotic exposure in critically ill patients were procured, and the most important covariates influencing this exposure were modelled. Integration of these results now allows returning to the patient's bedside with an optimized dosing regimen for ceftriaxone and meropenem. The randomized controlled trial planned in this postdoctoral project will allow for reliable evaluation of the clinical impact of dose optimization for ceftriaxone in critically ill patients, which will serve as a proof of concept for future studies (e.g., with meropenem). Furthermore, antibiotic dose optimization strategies will also be developed in children, as augmented renal clearance and the need for dose optimization have been showed to be equally important in children.

Keywords:Dose optimisation, Augmented renal clearance, Ceftriaxone, Meropenem, Pharmacokinetic

Disciplines:Medical intensive care, Pharmacokinetics, Pharmacodynamics, Pharmacotherapy, Infectious diseases