The neurobiology and psychology of late onset psychosis

Very-late-onset schizophrenia-like psychosis (VLOSLP) is an invalidating condition characterized by diffuse and mildly progressive cognitive dysfunction. In this PhD project we wish to research neurobiological and associated neuropsychological/behavioral factors that may contribute to the onset and persistence of VLOSLP. Specifically, we hypothesize that brain integrity and possibly neurodegenerative mechanisms may be involved in reducing a neurobiological and cognitive reserve, and thus triggering the onset of psychosis. Indeed, earlier research has identified similar aging-related white matter deficit patterns in patients with schizophrenia and Alzheimer’s disease. Also, there is evidence of accelerated cognitive decline and increased risk of developing dementia in elderly patients with schizophrenia. Therefore, we will analyze brain white matter integrity and amyloid deposition in a cross-sectional study comparing individuals with VLOSLP, a clinical control group of individuals with LOD and a healthy age and gender matched control group. Neurobiological data will be related to neuropsychological/behavioral assessments.