Dietary alterations in gut microbiota impact anti-tumor immunitytowards novel strategies to boost cancer immunotherapy. (R-11612)

Dietary factors have been shown to profoundly shape host immunity either by directly acting on immune cells or by indirectly affecting the gut microbiota. It was recently demonstrated that dietary factors could impact anti-tumor immunity as well as immunotherapy. Based on these findings, we will analyse alterations in gut microbiota and immune responses in respect to different diets in the context of cancer. We hypothesize that the proposed study will uncover diet-induced microbial signatures that promote anti-tumor immunity and thereby might lead to novel approaches for improving cancer immunotherapy.

Keywords:anti-tumor immunity, immunotherapy, microbiota, nutrition

Disciplines:Immunology not elsewhere classified