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Project

Mechanical and structural alterations after surgical treatment of knee osteoarthritis

Osteoarthritis (OA) is the most prevalent chronic joint disease. There is no cure to OA. Surgical treatment is performed in severe cases to reduce pain and to improve mobility. Visualization and quantification of bone microarchitecture in the human knee gives an opportunity to gain insight into normal bone structure, and into the structural changes occurring with OA progression. However, current imaging modalities have limitations in capturing the intricacies of bone microarchitecture in a patient. Although bone microarchitecture and ultrastructure can be non-invasively assessed using micro-computed tomography (Micro-CT), its applications is limited to ex vivo analyses, hence, it cannot be used to evaluate bone and bone adaptive responses in a patient. With this project we aimed to improve our understanding on subchondral bone microstructure and ultrastructure in end-stage knee OA, and to evaluate the accuracy of photon-counting CT (PCCT) for the measurement of bone quality in the knee.

Date:19 Jun 2019 →  22 Jan 2024
Keywords:Osteoarthritis
Disciplines:Tissue and organ biomechanics
Project type:PhD project