< Back to previous page

Publication

Multivalent Sgc8c-aptamer decorated polymer scaffolds for leukemia targeting

Journal Contribution - Journal Article

T-cell acute lymphoblastic leukemia causes a disproportional amount of immature white blood cells in the patients' bone marrow. The significant undesired side effects associated with traditional chemotherapy treatment prompted us to study a more effective treatment strategy. We decorated polyisocyanopeptide scaffolds with the selective leukemia cell binding aptamer sgc8c and found that the polymers inhibit proliferation by G0/G1-phase arrest, serving as an opportunity for future therapeutic strategies.
Journal: Chemical Communications
ISSN: 1359-7345
Issue: 22
Volume: 57
Pages: 2744 - 2747
Accessibility:Open