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Publication
SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts
Journal Contribution - Journal Article
PURPOSE: To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts.
METHODS: Immunohistochemistry and confocal microscopy on human primary oocytes and pre (5 days post fertilization (dpf5) and (dpf6))- and peri (dpf7)-implantation blastocysts donated to research.
RESULTS: SARS-CoV-2 host receptors ACE2 and CD147 are present on the membrane of trophectoderm, epiblast and hypoblast cells in human blastocysts. CD147 is also present on the oolemma.
CONCLUSION: Theoretically, the earliest stages of embryonic development may be vulnerable for SARS-CoV-2 infection.
Journal: Journal of Assisted Reproduction & Genetics
ISSN: 1058-0468
Issue: 11
Volume: 37
Pages: 2657-2660
Publication year:2020
CSS-citation score:1
Accessibility:Open