The role of TRPM4 in cardiac contractility and arrhythmias

TRPM4 is a Ca2+-activated non-selective cation channel that belongs to the family of the Transient Receptor Potential (TRP) ion channels. TRPM4 is a monovalent-selective cation channel, which is activated by an increase of the intracellular Ca2+ concentration. Trpm4 is highly expressed in the heart and was recently suggested as a novel regulator of ventricular contractility. Additionally, it was hypothesized before that TRPM4-like channels might play a role in the development of Ca2+-dependent triggered arrhythmias. Therefore, we investigated the role of TRPM4 in cardiac contractility and arrhythmias in living animals.

Publication year:2016

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