Extracellular vesicle (EV) transport across the brain barriers: from mechanistic and biological insights towards strategies for delivery of therapeutics to the brain.

Extracellular vesicles (EVs) are nanosized membrane vesicles released by a broad range of cells. We study the mechanism by which EVs cross the central nervous system (CNS) barriers using innovative EV-loading technologies and surface proteome analysis. Next, we use this knowledge to develop novel brain targeting strategies for drug delivery.