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Project

A microfluidic platform to screen engineered lasso peptides for therapeutic potential

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a rapidly expanding class of chemically and structurally-diverse bacterial natural products. Many exhibit therapeutically-important biological activities, such as antibiotic, antifungal, insecticidal, immunomodulating and anti-cancer activities. Although these natural RiPPs display potent activities, only a few of them are commercially available. Due to the extraordinary biosynthetic malleability of RiPPs, we believe that synthetic biology combined with a high-throughput microfluidics-based screening approach, can accelerate the development of macrocyclic RiPPs as clinical drugs.
Date:1 Jan 2021 →  31 Oct 2021
Keywords:Microfluidics, Post-translationally modified peptides, Bioactive natural products, (Bio-)Engineering
Disciplines:Microfluidics/flow chemistry, Characterisation of biologically active (macro)molecules, Other biotechnology, bio-engineering and biosystem engineering not elsewhere classified