Symmetry driven self-assembly of hybrid POM/Protein Frameworks (PProFs) based on rational protein design and metal-oxo clusters

The modern era of advanced materials requires the process of material engineering to be atom-economic and precise, leading to advanced materials that possess high performance, while being made of environmentally benign components via a sustainable route. Among the most well-known examples are the highly symmetrical metal-organic frameworks, which are reticular materials comprised of integrated organic and metal-based inorganic components. The unique combination of metals or metal-oxo clusters and organic ligands situates these MOFs on the interface between inorganic an organic chemistry. Following the same reasoning, creating a new hybrid material based on another interface between different fields would be possible. Working at the interface of biochemistry could pave the path to future material engineering.

Keywords:Protein design, Polyoxometalate, hybrid frameworks, crystallography, cryoEM

Disciplines:Structural biology, (Bio)molecular modelling and design